IN VITRO ANTIDIABETES AND ANTIHYPERTENSION PROPERTIES OF PHENOLIC EXTRACTS FROM BITTER LEAF (VERNONIA AMYGDALINA DEL.)
Identifieur interne : 001490 ( Main/Exploration ); précédent : 001489; suivant : 001491IN VITRO ANTIDIABETES AND ANTIHYPERTENSION PROPERTIES OF PHENOLIC EXTRACTS FROM BITTER LEAF (VERNONIA AMYGDALINA DEL.)
Auteurs : J. A. Saliu [Nigeria] ; A. O. Ademiluyi [Nigeria] ; A. J. Akinyemi [Nigeria] ; G. Oboh [Nigeria]Source :
- Journal of Food Biochemistry [ 0145-8884 ] ; 2012-10.
Abstract
Bitter leaf is a popular vegetable commonly consumed and which has been employed in traditional medicine for the prevention/management of diabetes and hypertension for centuries in the tropical Africa. However, possible mechanism underlining its hypoglycemic and antihypertension is not clear. Therefore, this study sought to investigate the inhibitory effect of free and bound phenol extracts of bitter leaf on key enzymes linked to type‐2 diabetes (α‐glucosidase and α‐amylase) and hypertension (angiotensin‐I converting enzyme [ACE]). The free and bound phenol extracts significantly (P < 0.05) inhibited α‐amylase and α‐glucosidase activities in vitro in a dose‐dependent pattern (4–16 µg/mL). However, the α‐glucosidase inhibitory activity of the extracts were significantly (P < 0.05) higher than their α‐amylase inhibitory activity. Furthermore, the ACE inhibitory activity of the extracts also followed a dose‐dependent pattern (5–20 µg/mL), and the bound phenol extract significantly (P < 0.05) inhibited ACE more than the free phenol extract. However, there exists a strong correlation between the enzyme inhibitory activities and the phenol content of the extracts. Therefore, the inhibition of α‐amylase, α‐glucosidase and ACE, coupled with the antioxidant activities of bitter leaf phenolic‐rich extracts, could be a possible mechanism through which Vernonia amygdalina exert its antidiabetes and antihypertension properties.
Url:
DOI: 10.1111/j.1745-4514.2011.00576.x
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000D79
- to stream Istex, to step Curation: 000D79
- to stream Istex, to step Checkpoint: 000160
- to stream Main, to step Merge: 001505
- to stream Main, to step Curation: 001490
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">IN VITRO ANTIDIABETES AND ANTIHYPERTENSION PROPERTIES OF PHENOLIC EXTRACTS FROM BITTER LEAF (VERNONIA AMYGDALINA DEL.)</title><author><name sortKey="Saliu, J A" sort="Saliu, J A" uniqKey="Saliu J" first="J. A." last="Saliu">J. A. Saliu</name></author><author><name sortKey="Ademiluyi, A O" sort="Ademiluyi, A O" uniqKey="Ademiluyi A" first="A. O." last="Ademiluyi">A. O. Ademiluyi</name></author><author><name sortKey="Akinyemi, A J" sort="Akinyemi, A J" uniqKey="Akinyemi A" first="A. J." last="Akinyemi">A. J. Akinyemi</name></author><author><name sortKey="Oboh, G" sort="Oboh, G" uniqKey="Oboh G" first="G." last="Oboh">G. Oboh</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:9AAAA8F4A15A0683DA571A79BC3B9CE6E1FE598D</idno><date when="2012" year="2012">2012</date><idno type="doi">10.1111/j.1745-4514.2011.00576.x</idno><idno type="url">https://api.istex.fr/document/9AAAA8F4A15A0683DA571A79BC3B9CE6E1FE598D/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000D79</idno><idno type="wicri:Area/Istex/Curation">000D79</idno><idno type="wicri:Area/Istex/Checkpoint">000160</idno><idno type="wicri:doubleKey">0145-8884:2012:Saliu J:in:vitro:antidiabetes</idno><idno type="wicri:Area/Main/Merge">001505</idno><idno type="wicri:Area/Main/Curation">001490</idno><idno type="wicri:Area/Main/Exploration">001490</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">IN VITRO ANTIDIABETES AND ANTIHYPERTENSION PROPERTIES OF PHENOLIC EXTRACTS FROM BITTER LEAF (VERNONIA AMYGDALINA DEL.)</title><author><name sortKey="Saliu, J A" sort="Saliu, J A" uniqKey="Saliu J" first="J. A." last="Saliu">J. A. Saliu</name><affiliation wicri:level="1"><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Biochemistry, Federal University of Technology, Akure, P.M.B. 704, Akure, 340001</wicri:regionArea><wicri:noRegion>340001</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Biochemistry, Adekunle Ajasin University, Akungba Akoko</wicri:regionArea><wicri:noRegion>Akungba Akoko</wicri:noRegion></affiliation></author><author><name sortKey="Ademiluyi, A O" sort="Ademiluyi, A O" uniqKey="Ademiluyi A" first="A. O." last="Ademiluyi">A. O. Ademiluyi</name><affiliation wicri:level="1"><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Biochemistry, Federal University of Technology, Akure, P.M.B. 704, Akure, 340001</wicri:regionArea><wicri:noRegion>340001</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Nigeria</country><wicri:regionArea>Biochemistry Unit, Department of Geological and Chemical Sciences, Osun State University, Osogbo P.M.B. 4494, Osogbo</wicri:regionArea><wicri:noRegion>Osogbo</wicri:noRegion></affiliation></author><author><name sortKey="Akinyemi, A J" sort="Akinyemi, A J" uniqKey="Akinyemi A" first="A. J." last="Akinyemi">A. J. Akinyemi</name><affiliation wicri:level="1"><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Biochemistry, Federal University of Technology, Akure, P.M.B. 704, Akure, 340001</wicri:regionArea><wicri:noRegion>340001</wicri:noRegion></affiliation></author><author><name sortKey="Oboh, G" sort="Oboh, G" uniqKey="Oboh G" first="G." last="Oboh">G. Oboh</name><affiliation wicri:level="1"><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Biochemistry, Federal University of Technology, Akure, P.M.B. 704, Akure, 340001</wicri:regionArea><wicri:noRegion>340001</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Food Biochemistry</title><idno type="ISSN">0145-8884</idno><idno type="eISSN">1745-4514</idno><imprint><publisher>Blackwell Publishing Inc</publisher><pubPlace>Malden, USA</pubPlace><date type="published" when="2012-10">2012-10</date><biblScope unit="volume">36</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="569">569</biblScope><biblScope unit="page" to="576">576</biblScope></imprint><idno type="ISSN">0145-8884</idno></series><idno type="istex">9AAAA8F4A15A0683DA571A79BC3B9CE6E1FE598D</idno><idno type="DOI">10.1111/j.1745-4514.2011.00576.x</idno><idno type="ArticleID">JFBC576</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0145-8884</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Bitter leaf is a popular vegetable commonly consumed and which has been employed in traditional medicine for the prevention/management of diabetes and hypertension for centuries in the tropical Africa. However, possible mechanism underlining its hypoglycemic and antihypertension is not clear. Therefore, this study sought to investigate the inhibitory effect of free and bound phenol extracts of bitter leaf on key enzymes linked to type‐2 diabetes (α‐glucosidase and α‐amylase) and hypertension (angiotensin‐I converting enzyme [ACE]). The free and bound phenol extracts significantly (P < 0.05) inhibited α‐amylase and α‐glucosidase activities in vitro in a dose‐dependent pattern (4–16 µg/mL). However, the α‐glucosidase inhibitory activity of the extracts were significantly (P < 0.05) higher than their α‐amylase inhibitory activity. Furthermore, the ACE inhibitory activity of the extracts also followed a dose‐dependent pattern (5–20 µg/mL), and the bound phenol extract significantly (P < 0.05) inhibited ACE more than the free phenol extract. However, there exists a strong correlation between the enzyme inhibitory activities and the phenol content of the extracts. Therefore, the inhibition of α‐amylase, α‐glucosidase and ACE, coupled with the antioxidant activities of bitter leaf phenolic‐rich extracts, could be a possible mechanism through which Vernonia amygdalina exert its antidiabetes and antihypertension properties.</div></front></TEI><affiliations><list><country><li>Nigeria</li></country></list><tree><country name="Nigeria"><noRegion><name sortKey="Saliu, J A" sort="Saliu, J A" uniqKey="Saliu J" first="J. A." last="Saliu">J. A. Saliu</name></noRegion><name sortKey="Ademiluyi, A O" sort="Ademiluyi, A O" uniqKey="Ademiluyi A" first="A. O." last="Ademiluyi">A. O. Ademiluyi</name><name sortKey="Ademiluyi, A O" sort="Ademiluyi, A O" uniqKey="Ademiluyi A" first="A. O." last="Ademiluyi">A. O. Ademiluyi</name><name sortKey="Akinyemi, A J" sort="Akinyemi, A J" uniqKey="Akinyemi A" first="A. J." last="Akinyemi">A. J. Akinyemi</name><name sortKey="Oboh, G" sort="Oboh, G" uniqKey="Oboh G" first="G." last="Oboh">G. Oboh</name><name sortKey="Saliu, J A" sort="Saliu, J A" uniqKey="Saliu J" first="J. A." last="Saliu">J. A. Saliu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Bois/explor/OrangerV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001490 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001490 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Bois
|area= OrangerV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:9AAAA8F4A15A0683DA571A79BC3B9CE6E1FE598D
|texte= IN VITRO ANTIDIABETES AND ANTIHYPERTENSION PROPERTIES OF PHENOLIC EXTRACTS FROM BITTER LEAF (VERNONIA AMYGDALINA DEL.)
}}
| This area was generated with Dilib version V0.6.25. |  |